carbamazepine (chewable) related liver function test * Warning : The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. Decreased values for thyroid function tests have been observed with carbamazepine administration. One study reported decreased serum levels of T4, FT4, and T3. In that study, TSH concentrations were not significantly altered. Clinicians should be cognizant of these effects when prescribing or administering carbamazepine therapy to patients with thyroid disorders. Alterations in liver function tests may progress to hepatotoxicity including cholangitis, granuloma formation, fever and hepatocellular necrosis. Discontinuation of carbamazepine often results in improvement in laboratory abnormalities and liver injury. Introduction Carbamazepine is an aromatic anticonvulsant that is widely used in therapy of epilepsy and trigeminal neuralgia and is a well established cause of clinically apparent liver injury which can be severe and even fatal. Routine monitoring of liver function tests is not recommended during TPM therapy. 64 Valproic acid (VPA) VPA has a broad spectrum of activity against both focal and generalized epilepsies. This study was conducted to assess the effect of carbamazepine, sodium valproate and phenytoin on serum liver enzymes in 49 epileptic patients admitted to the neurology outpatient clinic at Beni-Suef University between February 2010 and June 2011. Tegretol (carbamazepine) is an anticonvulsant used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. Tegretol is also used to treat bipolar disorder. Liver function tests should also be performed before commencing treatment and periodically thereafter, particularly in patients with a history of liver disease and in elderly patients. The drug should be withdrawn immediately in cases of aggravated liver dysfunction or acute liver disease. BRIEF REPORTS Effect of Carbamazepine on Serum Lipids and Liver Function Tests Anju Aggarwal, Manish Kumar and M.M.A Faridi From the Department of Pediatrics, University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi 110 095, India. Perform liver function tests to ascertain if liver damage has occurred. Obtain a complete blood count with differential (rarely, hematologic adverse effects, including agranulocytosis, thrombocytopenia, and aplastic anemia, have been reported with long-term carbamazepine use [ 11 ] ).